After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.

With computer genius Luther Stickell at his side and a beautiful thief on his mind, agent Ethan Hunt races across Australia and Spain to stop a former IMF agent from unleashing a genetically engineered biological weapon called Chimera. This mission, should Hunt choose to accept it, plunges him into the center of an international crisis...

Retired from active duty, and training recruits for the Impossible Mission Force, agent Ethan Hunt faces the toughest foe of his career: Owen Davian, an international broker of arms and information, who's as cunning as he is ruthless. Davian emerges to threaten Hunt and all that he holds dear – including the woman Hunt loves.

Molly Mahoney is the awkward and insecure manager of Mr. Magorium's Wonder Emporium—the strangest, most fantastic and most wonderful toy store in the world. After Mr. Magorium bequeaths the store to her, a dark and ominous change begins to take over the once-remarkable Emporium.

The Dynamic Duo faces four super-villains who plan to hold the world for ransom with the help of a secret invention that instantly dehydrates people.