Victor Frankenstein is a promising young doctor who, devastated by the death of his mother during childbirth, becomes obsessed with bringing the dead back to life. His experiments lead to the creation of a monster, which Frankenstein has put together with the remains of corpses. It's not long before Frankenstein regrets his actions.

A noted professor and his dim-witted apprentice fall prey to their inquiring vampires, while on the trail of the ominous damsel in distress.

The Wolf Man tries to warn a dimwitted porter that Dracula wants his brain for Frankenstein monster's body.

Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.

One of the sons of late Dr. Henry Frankenstein finds his father's ghoulish creation in a coma and revives him, only to find out the monster is controlled by Ygor who is bent on revenge.