Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.

When an old friend brings filmmaker Enrique Goded a semi-autobiographical script chronicling their adolescence, Enrique is forced to relive his youth spent at a Catholic boarding school. Weaving through past and present, the script follows a transvestite performer who reconnects with a grade school sweetheart. Spurred on by this chance...

After Silvia Broome, an interpreter at United Nations headquarters, overhears plans of an assassination, an American Secret Service agent is sent to investigate.

Slevin is mistakenly put in the middle of a personal war between the city’s biggest criminal bosses. Under constant watch, Slevin must try not to get killed by an infamous assassin and come up with an idea of how to get out of his current dilemma.

Some of Sin City's most hard-boiled citizens cross paths with a few of its more reviled inhabitants.