Vampires and werewolves have waged a nocturnal war against each other for centuries. But all bets are off when a female vampire warrior named Selene, who's famous for her strength and werewolf-hunting prowess, becomes smitten with a peace-loving male werewolf, Michael, who wants to end the war.

An ex-fighter pilot is forced to take over the controls of an airliner when the flight crew succumbs to food poisoning.

American tourists David and Jack are savagely attacked by an unidentified animal while hiking on the Yorkshire Moors. After retiring to the home of a beautiful nurse to recuperate, David soon begins experiencing disturbing changes to his body and mind.

As the war between the vampires and the Lycans rages on, Selene, a former member of the Death Dealers (an elite vampire special forces unit that hunts werewolves), and Michael, the werewolf hybrid, work together in an effort to unlock the secrets of their respective bloodlines.

Scotland Yard investigators have to prevent the murder of Victoria Dickman when her name is found on a death list.