In the year 2019, a plague has transformed almost every human into vampires. Faced with a dwindling blood supply, the fractured dominant race plots their survival; meanwhile, a researcher works with a covert band of vampires on a way to save humankind.

A group of delinquents are sent to clean the Blackwell Hotel but little do they know reclusive psychopath Jacob Goodnight has holed away in the rotting hotel. When one of the teens is captured, those who remain band together to survive against the brutal killer.

Residents of peaceful Pebbles Court, Homesville, are being used unknowingly as test experiments for a new 'Body Drug' that causes rapid body decomposition (melting skin etc.) and painful death.