Muktha Srinivasan entered the film industry in 1947, as Senior Assistant to T. R. Sundaram, by coaching artists in dialogue delivery. He worked with Chief Minister M. Karunanidhi in Manthiri Kumari and with major artists of the time including T. R. Mahalingam, Anjali Devi, Madhuri Devi, S. Balachandar and L. V. Prasad. He worked with Director K. Ramnoth as assistant along with K. S. Sethumathavan.