Mathilde La Musse (sometimes credited as Mathilde Lamusse) is a French actress and director.

She began her career in the mid-2010s, appearing in short films, television series, and music videos. In cinema, she gained recognition playing one of the lead roles in the horror film Kandisha (2020) and appearing in Leyla Bouzid's A Tale of Love and Desire (Une histoire d'amour et de désir, 2021). In 2023, she starred as Lili in Caroline Glorion's drama Like a She-Wolf (Comme une louve).

On television and streaming platforms, her credits include series such as Amours solitaires (2020), Narvalo (2020), Standing Up (Drôle, 2021), and Children Are Kings (Les Enfants sont rois, 2024). Alongside her acting career, she has directed short films, including Deux heures par semaine (2022).