A down-and-out Brooklyn detective is hired to track down a singer on an odyssey that will take him through the desperate streets of Harlem, the smoke-filled jazz clubs of New Orleans, and the swamps of Louisiana and its seedy underworld of voodoo.

Conducting clandestine experiments within the morgue at Miskatonic University, scientist Herbert West reveals to a fellow graduate student his groundbreaking work concerning the re-animation of fresh corpses.

Reporter John Klein is plunged into a world of impossible terror when fate draws him to the sleepy West Virginia town of Point Pleasant, whose residents are being visited by a great winged shape that sows hideous nightmares and fevered visions.

Baron Victor Frankenstein has discovered life's secret and unleashed a blood-curdling chain of events resulting from his creation: a cursed creature with a horrid face — and a tendency to kill.

A deformed tormented girl drowns herself after her lover is framed for murder and guillotined. Baron Frankenstein, experimenting with the transfer of souls, places the boy's soul into her body, bringing Christina back to life. Driven by revenge, she carries out a violent retribution on those responsible for both deaths.