Wounded Civil War soldier John Dunbar tries to commit suicide—and becomes a hero instead. As a reward, he's assigned to his dream post, a remote junction on the Western frontier, and soon makes unlikely friends with the local Sioux tribe.

As the west rapidly becomes civilized, a pair of outlaws in 1890s Wyoming find themselves pursued by a posse and decide to flee to South America in hopes of evading the law.

In early 20th-century Montana, Col. William Ludlow lives on a ranch in the wilderness with his sons, Alfred, Tristan, and Samuel. Eventually, the unconventional but close-knit family are bound by loyalty, tested by war, and torn apart by love, as told over the course of several decades in this epic saga.

In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

At the behest of local revolutionaries, a mercenary enlists four specialists in various combat styles to help him rob a Mexican Army train carrying $500,000 in gold.