A student film production is threatened when its faculty advisor unexpectedly dies. A guest artist agrees to help them, but the star of their movie -- a ravenous monster -- is not amused.

A group of American tourists heading down an African river make a brief stop at Snake Island, an island that has been virtually abandoned for years. When they end up getting trapped on the island overnight, they find thousands of deadly snakes intent on reclaiming the tropical island for themselves.