In 2257, a taxi driver is unintentionally given the task of saving a young girl who is part of the key that will ensure the survival of humanity.

Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.

In the midst of trying to legitimize his business dealings in 1979 New York and Italy, aging mafia don, Michael Corleone seeks forgiveness for his sins while taking a young protege under his wing.

Vampires and werewolves have waged a nocturnal war against each other for centuries. But all bets are off when a female vampire warrior named Selene, who's famous for her strength and werewolf-hunting prowess, becomes smitten with a peace-loving male werewolf, Michael, who wants to end the war.

A former Prohibition-era Jewish gangster returns to the Lower East Side of Manhattan over thirty years later, where he once again must confront the ghosts and regrets of his old life.