A master thief coincidentally is robbing a house where a murder—in which the President of the United States is involved—occurs in front of his eyes. He is forced to run, while holding evidence that could convict the President.

Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.

Some of Sin City's most hard-boiled citizens cross paths with a few of its more reviled inhabitants.

A cop, his partner, and his father uncover a plot by city elders to smuggle drugs from Mexico into Phoenix, Arizona.

While doing a friend a favor and searching for a runaway teenager, a police detective stumbles upon a bizarre band of criminals about to pull off a bank robbery.