A killer is on the loose, and an FBI agent sifts through clues and learns that the bloodthirsty felon's victims of choice are other serial killers.

When a notorious German serial killer is captured after committing some of the most heinous acts against humanity ever imaginable, a farmer and police officer from a sleepy rural community on the outskirts of Berlin is drawn into the case as he searches for the answers to a murder that has shaken his tight-knit community.

The Law Enforcement Technology Advancement Centre (LETAC) has developed SID version 6.7: a Sadistic, Intelligent, and Dangerous virtual reality entity which is synthesized from the personalities of more than 150 serial killers, and only one man can stop him.

Former FBI Agent Will Graham, who was once almost killed by the savage Hannibal 'The Cannibal' Lecter, now has no choice but to face him again, as it seems Lecter is the only one who can help Graham track down a new serial killer.

Still recovering from a heart transplant, a retired FBI profiler returns to service when his own blood analysis offers clues to the identity of a serial killer.