Following the tragic death of her teenage son, Manuela travels from Madrid to Barcelona in an attempt to contact the long-estranged father the boy never knew. She reunites with an old friend, an outspoken transgender sex worker, and befriends a troubled actress and a pregnant, HIV-positive nun.

Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.

In the late 1940s, a murderous couple known as the 'The Lonely Hearts Killers' kills close to a dozen people. Two detectives try to nab the duo who find their targets via the personals in the paper.

A veteran high school teacher befriends a younger art teacher, who is having an affair with one of her 15-year-old students. However, her intentions with this new "friend" also go well beyond platonic friendship.

Elizabeth has just been through a particularly nasty breakup, and now she's ready to leave her friends and memories behind as she chases her dreams across the country. In order to support herself on her journey, Elizabeth picks up a series of waitress jobs along the way. As Elizabeth crosses paths with a series of lost souls whose year...