Lady scientist, Hilary Parker is searching for a rare drug to help combat polio. Opportunist Bruce Edwards joins the quest but is actually after gold and buried treasure.

Football player Bob Miller, played by an actual football player, is lost in the jungle. Who else to find him but Jungle Jim.

Jungle Jim must protect rare pony-like animals whose glands produce a powerful narcotic. On the way, he fights a giant spider.

Jungle Jim is forced to lead anthropologist Dr. Edwards into a land inhabited by giant people.

Nasty white hunters are testing out their germ warfare weapons using wild animals in Africa… until they run into Jungle Jim.