Four young women continue the journey toward adulthood that began with "The Sisterhood of the Traveling Pants." Now three years later, these lifelong friends embark on separate paths for their first year of college and the summer beyond, but remain in touch by sharing their experiences with each other.

After arriving at his new, remote Army outpost, Capt. John Boyd and his regiment aid a wounded frontiersman who recounts a horrifying tale of a wagon train murdered by its supposed guide – a vicious U.S. Army colonel gone rogue. Fearing the worst, the regiment heads out into the wilderness to verify the gruesome claims.

When Manny Singer's wife dies, his young daughter Molly becomes mute and withdrawn. To help cope with looking after Molly, he hires sassy housekeeper Corrina Washington, who coaxes Molly out of her shell and shows father and daughter a whole new way of life. Manny and Corrina's friendship delights Molly and enrages the other townspeople.

A young girl inhabits an isolated island with her scientist father and communicates with a reclusive author of the novel she's reading.

Oscar is a small fish whose big aspirations often get him into trouble. Meanwhile, Lenny is a great white shark with a surprising secret that no sea creature would guess: He's a vegetarian. When a lie turns Oscar into an improbable hero and Lenny becomes an outcast, the two form an unlikely friendship.