During China's Tang dynasty the emperor has taken the princess of a neighboring province as his wife. She has borne him two sons and raised his eldest. Now his control over his dominion is complete, including the royal family itself.

The Turtles and the Shredder battle once again, this time for the last cannister of the ooze that created the Turtles, which Shredder wants to create an army of new mutants. Meanwhile Splinter is coming... to a decision.

A quartet of humanoid turtles, trained by their mentor in Ninjutsu, must learn to work together to face the menace of Shredder and the Foot Clan.

The four turtles travel back in time to the days of the legendary and deadly samurai in ancient Japan, where they train to perfect the art of becoming one. The turtles also assist a small village in an uprising.

Young Scottish doctor, Nicholas Garrigan decides it's time for an adventure after he finishes his formal education, so he decides to try his luck in Uganda, and arrives during the downfall of President Obote. General Idi Amin comes to power and asks Garrigan to become his personal doctor.