Retired police lieutenant Al Giardello is running for mayor when he is suddenly shot at a press conference. All of the detectives, past and present, clamor for an opportunity to help find the shooter.

When a cockroach-spread plague threatened to decimate the child population of New York City in the original Mimic, biologist Susan Tyler and her research associates developed a species of "Judas" bugs and introduced them into the environment, where they were to "mimic" the diseased roaches and infiltrate their grubby habitats. The plan...

NYPD Detective Mike Logan, who was demoted to a beat on Staten Island after punching a corrupt politician, seeks to solve the grisly murder of a prostitute and thereby help regain his old job in Manhattan.

The year is 2048, and global warming has flooded much of Earth's land areas. A father and his two sons try to salvage treasures from sunken buildings when they are given an important assignment by the New Vatican.