Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minu...

After being hit by an iron rod, Sanjay Ramaswamy, a business tycoon, suffers from anterograde amnesia. He is unable to remember anything beyond fifteen minutes. Under such circumstances, he sets out on a quest to find the people who were responsible for his lover Kalpana's murder.