Two not-too-bright party girls reinvent themselves for their high school reunion. Armed with a borrowed Jaguar, new clothes and the story of their success as the inventors of Post-It notes, Romy and Michele descend on their alma mater, but their façade crumbles quickly.

Blonde, bouncy Buffy is your typical high school cheerleader. But all that changes when a strange man informs her she's been chosen by fate to kill vampires.

After witnessing a mysterious woman brutally slay a homemaker, prostitute Liz Blake finds herself trapped in a dangerous situation. While the police thinks she is the murderer, the real killer is intent on silencing her only witness.

With global superpowers engaged in an increasingly hostile arms race, Superman leads a crusade to rid the world of nuclear weapons. But Lex Luthor, recently sprung from jail, is declaring war on the Man of Steel and his quest to save the planet. Using a strand of Superman's hair, Luthor synthesizes a powerful ally known as Nuclear Man ...

The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines, and discovers a brilliant formula that reverses aging. But Sherman's thin and obnoxious alter ego, Buddy Love, wants out...and a big piece of the action. And when Buddy gets loose, things get seriously nutty.