A man who specializes in debunking paranormal occurrences checks into the fabled room 1408 at the Dolphin Hotel. Soon after settling in, he confronts genuine terror.

After a violent storm, a dense cloud of mist envelops a small Maine town, trapping David Drayton and his five-year-old son in a local grocery store with other local residents. They soon discover that the mist conceals deadly horrors that threaten their lives, and worse, their sanity.