A man who specializes in debunking paranormal occurrences checks into the fabled room 1408 in the Dolphin Hotel. Soon after settling in, he confronts genuine terror.

After a violent storm, a dense cloud of mist envelops a small Maine town, trapping artist David Drayton and his five-year-old son in a local grocery store with other people. They soon discover that the mist conceals deadly horrors that threaten their lives, and worse, their sanity.