Joel Barish, heartbroken that his girlfriend underwent a procedure to erase him from her memory, decides to do the same. However, as he watches his memories of her fade away, he realises that he still loves her, and may be too late to correct his mistake.

Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.

Suffering from insomnia, disturbed loner Travis Bickle takes a job as a New York City cabbie, haunting the streets nightly, growing increasingly detached from reality as he dreams of cleaning up the filthy city.

The life of boxer Jake LaMotta, whose violence and temper that led him to the top in the ring destroyed his life outside of it.

After living abroad, Lana returns to the United States, and finds that her uncle is a reclusive vagabond with psychic wounds from the Vietnam War.