Rizwan Khan, a Muslim from the Borivali section of Mumbai, has Asperger's syndrome. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his condition and his race.

Anjali is left heartbroken when her best friend and secret crush, Rahul, falls in love with Tina. Years later, Tina's young daughter tries to fulfil her mother's last wish of uniting Rahul and Anjali.

Rahul, the adoptive son of business magnate Yash Raichand, feels eternal gratitude to his father for rescuing him from a life of poverty. Yet, when Yash forbids his love of poor Anjali, Rahul marries her and moves to London with new wife and sister-in-law, breaking the heart of his mother. Ten years later, Rahul's younger brother comes...

Wake Up Sid! is the story of a lazy Mumbai college student who does absolutely nothing, with a turn of events will Sid realize his potential in this world and become a success in the fast-paced life of Mumbai.

Dev and Maya are both married to different people. Settled into a life of domestic ritual, and convinced that they are happy in their respective relationships, they still yearn for something deeper and more meaningful, which is precisely what they find in each other.