The residents of San Francisco are becoming drone-like shadows of their former selves, and as the phenomenon spreads, two Department of Health workers uncover the horrifying truth.

A soldier from Earth crashlands on an alien world after sustaining battle damage. Eventually he encounters another survivor, but from the enemy species he was fighting; they band together to survive on this hostile world. In the end the human finds himself caring for his enemy in a completely unexpected way.

Video game expert Alex Rogan finds himself transported to another planet after conquering the video game The Last Starfighter, only to find out it was just a test. He was recruited to join the team of best Starfighters to defend their world from the attack.

A scientist, Dr. Hollander, takes his niece Miranda to Mexico in an attempt to reverse the effects of the alien DNA he used to create her. However the treatment goes horribly wrong, and sets Miranda on a killing spree as she sets out to find a mate.

After a battle with Dr. Animo in a power plant, Ben notices something strange is happening with the Omnitrix but doesn't tell anyone. Tetrax arrives and tells them the Omnitrix is broadcasting a self-destruct signal. Tetrax and Ben go to find the creator of the Omnitrix to fix it before it destroys itself and the universe along with it...