Jake Blues, just released from prison, puts his old band back together to save the Catholic home where he and his brother Elwood were raised.

Following a childhood tragedy, Dewey Cox follows a long and winding road to music stardom. Dewey perseveres through changing musical styles, an addiction to nearly every drug known and bouts of uncontrollable rage.

Heinz Strunk, plagued by crater-like skin rashes, lives with his sick mother in Hamburg-Harburg in the 1980s. As a saxophonist, he tours the North German lowlands with the dance combo "Tiffanys". In this bizarre universe of Korn, Klaus & Klaus and Koteletts, bandleader Gurki teaches him how to deliver cheerful, upbeat music. To escape ...

Finally released from prison, Elwood Blues is once again enlisted by Sister Mary Stigmata in her latest crusade to raise funds for a children's hospital. Hitting the road to re-unite the band and win the big prize at the New Orleans Battle of the Bands, Elwood is pursued cross-country by the cops.

A wanna-be blues guitar virtuoso seeks a long-lost song by legendary musician, Robert Johnson.