In 2257, a taxi driver is unintentionally given the task of saving a young girl who is part of the key that will ensure the survival of humanity.

As the war between the vampires and the Lycans rages on, Selene, a former member of the Death Dealers (an elite vampire special forces unit that hunts werewolves), and Michael, the werewolf hybrid, work together in an effort to unlock the secrets of their respective bloodlines.

In 2019, Lincoln Six-Echo is a resident of a seemingly "Utopian" but contained facility. Like all of the inhabitants of this carefully-controlled environment, Lincoln hopes to be chosen to go to The Island — reportedly the last uncontaminated location on the planet. But Lincoln soon discovers that everything about his existence is a lie.

In a dystopian future, a totalitarian regime maintains peace by subduing the populace with a drug, and displays of emotion are punishable by death. A man in charge of enforcing the law rises to overthrow the system.

In the late 21st century, a subculture of humans have emerged who have been modified genetically by a vampire-like disease, giving them enhanced speed, incredible stamina and acute intelligence. As they are set apart from "normal" and "healthy" humans, the world is pushed to the brink of worldwide civil war aimed at the destruction of...